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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN9
All Species:
31.82
Human Site:
Y366
Identified Species:
63.64
UniProt:
P43378
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43378
NP_002824.1
593
68020
Y366
N
A
S
F
M
D
G
Y
K
Q
K
N
A
Y
I
Chimpanzee
Pan troglodytes
XP_001144390
596
67599
Y366
N
A
S
F
M
D
G
Y
K
Q
K
N
A
Y
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_854411
607
69728
Y380
N
A
S
F
M
D
G
Y
K
Q
K
N
A
Y
I
Cat
Felis silvestris
Mouse
Mus musculus
O35239
593
67952
Y366
N
A
S
F
M
D
G
Y
K
Q
K
N
A
Y
I
Rat
Rattus norvegicus
Q641Z2
593
67944
Y366
N
A
S
F
M
D
G
Y
K
Q
K
N
A
Y
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505361
613
70033
M383
D
Y
I
N
A
S
Y
M
D
G
Y
K
Q
R
N
Chicken
Gallus gallus
XP_413696
584
66275
G356
I
N
A
S
F
M
D
G
Y
K
Q
R
N
A
Y
Frog
Xenopus laevis
NP_001081203
694
79518
Y464
N
A
S
F
M
D
G
Y
K
R
K
N
A
Y
I
Zebra Danio
Brachydanio rerio
XP_001923429
571
65239
R336
T
R
V
R
L
K
A
R
R
N
E
R
S
D
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_727356
797
85738
Y566
N
A
N
F
V
D
G
Y
K
Q
K
N
A
Y
I
Honey Bee
Apis mellifera
XP_394701
660
73346
Y428
N
A
N
F
V
D
G
Y
K
Q
K
N
A
F
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001200442
281
32148
Q58
K
N
A
F
I
A
T
Q
G
A
L
P
K
T
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.9
N.A.
92
N.A.
97.3
97.1
N.A.
75.8
74
44.3
67.7
N.A.
35.6
43.4
N.A.
25.8
Protein Similarity:
100
94.6
N.A.
94.4
N.A.
98.6
98.9
N.A.
87.4
84.4
61
81.6
N.A.
49.1
60.6
N.A.
34.2
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
0
0
93.3
0
N.A.
86.6
80
N.A.
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
6.6
20
100
26.6
N.A.
100
100
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
67
17
0
9
9
9
0
0
9
0
0
67
9
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
67
9
0
9
0
0
0
0
9
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% E
% Phe:
0
0
0
75
9
0
0
0
0
0
0
0
0
9
9
% F
% Gly:
0
0
0
0
0
0
67
9
9
9
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
0
9
0
9
0
0
0
0
0
0
0
0
0
67
% I
% Lys:
9
0
0
0
0
9
0
0
67
9
67
9
9
0
0
% K
% Leu:
0
0
0
0
9
0
0
0
0
0
9
0
0
0
0
% L
% Met:
0
0
0
0
50
9
0
9
0
0
0
0
0
0
0
% M
% Asn:
67
17
17
9
0
0
0
0
0
9
0
67
9
0
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
9
0
59
9
0
9
0
0
% Q
% Arg:
0
9
0
9
0
0
0
9
9
9
0
17
0
9
0
% R
% Ser:
0
0
50
9
0
9
0
0
0
0
0
0
9
0
0
% S
% Thr:
9
0
0
0
0
0
9
0
0
0
0
0
0
9
0
% T
% Val:
0
0
9
0
17
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
9
67
9
0
9
0
0
59
17
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _